Landmark Clinical Trials
Learning Early About Peanut Allergy (LEAP)
Key Outcomes: An 81% reduction of peanut allergy in high-risk infants who consumed the study-recommended amount of peanut protein per week for the suggested time period. Preferred peanut source was Bamba, a snack food manufactured from peanut butter and puffed maize. Smooth peanut butter was provided to infants who did not like Bamba.
Takeaways: LEAP established that sustained introduction of peanut beginning in the first 11 months was highly effective in preventing the development of peanut allergy. A follow-up study (LEAP-ON) later demonstrated that the same infants remained allergy-free through their 4th year of avoiding peanuts.
Enquiring About Tolerance (EAT)
Key Outcomes: A 67% reduction in the prevalence of overall food allergy, 100% reduction in peanut allergy, and 75% reduction in egg allergy in the early introduction group
Takeaways: Early introduction of allergenic foods starting at 3 months compared to starting after 6 months was both safe and demonstrated a significant reduction in food allergy prevalence, suggesting that there are more benefits to introducing allergens earlier rather than later and as early as 3 months. One of the key findings from the study established that early allergen introduction did not negatively impact breastfeeding practices. However, study participants could only achieve 50% compliance with protocol, indicating that early and sustained introduction was difficult to achieve at such a young age.
Prevention of Egg Allergy with Tiny Amount Intake (PETIT)
Key Outcomes: A 79% reduction in egg allergy prevalence among infants with eczema who consumed the study-recommended amount of cooked egg protein per week
Takeaways: Stepwise introduction of egg safely and effectively prevents the development of egg allergies in children.
Delaying introduction of egg may actually
increase the incidence of food allergies.
5 Key Rules For Early Allergen Introduction To Prevent 4 out of 5 Food Allergies:
Studies recommend starting as early as 4-6 months, to align with a critical immune window, giving your infant the best opportunity to develop a positive response to new foods.
|Introduce One Food At A Time:|
Following pediatric guidelines, only introduce allergenic foods one at a time every few days, to determine how the baby is reacting to each new food. Ready, Set, Food! introduces one new food at a time, in accordance with these guidelines.
|Start with a Low Dose, Then Gradually Ramp Up Dosage:|
The PETIT study and leading pediatricians recommend this dosing as it maximizes safety and efficacy. Ready, Set, Food! aligns with this guidance, as it starts with a low dose and gradually increases to the full dose.
|Continue Multiple Times A Week For Several Months:|
Clinical trials exposed infants to allergenic foods 2-7 times a week for 3-6+ months. Families unable to maintain this frequent feeding did not see any benefit of food allergy prevention.
|Keep Going, Despite Difficulties:|
Many 4-6-month-olds are not ready to eat solid foods regularly and can be picky eaters. Despite these difficulties, continuing allergen introduction is crucial. For long-lasting immunity, research shows that “educating” an infant’s immune system over time is vital to creating tolerance.
Top Resources for You
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